OSAKA -- A Japanese research team is making progress on the development of a groundbreaking medication that may allow people to grow new teeth, with clinical trials set to begin in July 2024.
The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital factors. The team is aiming to have it ready for general use in 2030.
In prior animal experiments, the medicine prompted the growth of "third-generation" teeth following baby teeth and then permanent adult teeth.
"The idea of growing new teeth is every dentist's dream. I've been working on this since I was a graduate student. I was confident I'd be able to make it happen," said Katsu Takahashi, lead researcher and head of the dentistry and oral surgery department at the Medical Research Institute Kitano Hospital in the city of Osaka.
Anodontia is a congenital condition that causes the growth of fewer than a full set of teeth, present in around 1% of the population. Genetic factors are thought to be the major cause for the one-tenth of anodontia patients who lack six or more teeth, a condition categorized as oligodontia. These conditions are also known as tooth agenesis. People who grow up with tooth agenesis struggle with basic abilities like chewing, swallowing and speaking from a young age, which can negatively impact their development.
After completing a dentistry degree, Takahashi went on to graduate studies in molecular biology at Kyoto University in 1991. Afterwards, he studied in the U.S.
Around that time, research around the world had begun to pinpoint genes that, when deleted, would cause genetically modified mice to grow fewer teeth. "The number of teeth varied through the mutation of just one gene. If we make that the target of our research, there should be a way to change the number of teeth (people have)," Takahashi said of his thoughts at the time.
It was around 2005, when he delved further into the subject at Kyoto University after returning to Japan, that he began to see a bright path for his continued research. The researchers found that mice lacking a certain gene had an increased number of teeth. A protein called USAG-1, synthesized by the gene, was found to limit the growth of teeth. In other words, blocking the action of that protein could allow more teeth to grow.